The effect of plant extracts on immune function: enhance hematopoietic function by affecting the hematopoietic system
- Categories:Driving Force Magazine
- Author:Guangzhou Suntheme
- Origin:
- Time of issue:2020-11-03
- Views:971
(Summary description)
The effect of plant extracts on immune function: enhance hematopoietic function by affecting the hematopoietic system
(Summary description)
- Categories:Driving Force Magazine
- Author:Guangzhou Suntheme
- Origin:
- Time of issue:2020-11-03
- Views:971
my country has a long history of research on the application of plants to humans and animals. Plant extracts have a variety of physiological functions such as antibacterial, anti-oxidation, improvement of intestinal health, and enhancement of immune function. They are one of the ideal substitutes for antibiotics. Plant extracts contain biologically active substances such as alkaloids, polyphenols, flavonoids, polysaccharides, and volatile oils, which are closely related to immune function (Liu Zhengxu et al., 2014).
Plant extracts improve immune function and it affects the hematopoietic system and enhances hematopoietic function.
Has obvious promotion of hematopoietic function
In the traditional sense, we believe that Angelica sinensis, Chinese wolfberry, Polygonum multiflorum, Radix Astragali, Codonopsis pilosula, etc., which can nourish qi and nourish blood, have been shown to have obvious pharmacologically promoting hematopoietic function.
"Traditional Chinese Medicine Pharmacology" (Sun Jianning) pointed out that ginseng, dangshen, astragalus, angelica, donkey-hide gelatin, fleece-flower root, etc. can enhance bone marrow hematopoietic function, increase animal red blood cells, white blood cells, and hemoglobin, which is essential for regulating the body's immune function.
"Modern Red Blood Cell Immunology" (Guo Feng, 2002) elaborated on the effects of traditional Chinese medicine on red blood cell immunity. Astragalus and Atractylodes macrocephala with the function of replenishing qi can improve the body's disease resistance by improving the immune function of red blood cells and lymphocytes. Ganoderma lucidum polysaccharide can significantly improve the immune adhesion function of red blood cells in animals, enhance the SOD enzyme activity of red blood cells, and then play a role in regulating immunity and anti-aging. Chinese herbal medicine has a regulatory effect on red blood cell immune function, and enhances the body's immune function within a certain dose range. In practice, it can play an important role in anti-infection, anti-tumor, and disease prevention and treatment by regulating the red blood cell immune function.
How to improve hematopoietic function
The mechanism of how plant extracts improve hematopoietic function is more complicated. It may promote the production of red blood cells, bone marrow cells, etc. by affecting hematopoietic factors or negative hematopoietic regulatory factors in the hematopoietic system, thereby enhancing hematopoietic function. Angelica polysaccharides in Angelica sinensis can regulate the production of blood cells by directly or indirectly up-regulating the secretion of hematopoietic growth factors by endothelial cells in the hematopoietic microenvironment, increasing the number of hematopoietic stem cells, peripheral red blood cells and white blood cells, and increasing hemoglobin (Mao Yu et al., 2015). Lycium barbarum polysaccharide can promote the proliferation of hematopoietic stem cells and granulo-monolineage progenitor cells, and increase the proportion of red blood cells in the peripheral blood network tissue. Liu et al. found that 7 plant extracts (anisol, capsicum oleoresin, carvacrol, cinnamaldehyde, eugenol, allicin, turmeric resin) can significantly inhibit the expression of tumor necrosis factor TNF-α (TNF- α is one of the negative regulatory factors of hematopoiesis. It is a cytokine secreted by T lymphocytes activated by endogenous or exogenous stimulation, which can inhibit bone marrow hematopoiesis), and has different degrees of anti-inflammatory effects (Liu et al., 2012; Yao Yong) Et al., 2013).
Immunomodulatory effects of plant extracts
Plant extracts play an immunomodulatory effect by promoting hematopoietic function, which plays an important role in animal resistance to diseases.
"Modern Red Blood Cell Immunology" (Guo Feng, 2002) believes that red blood cells are also immune cells, and the immune function of red blood cells is no less than that of white blood cells and is irreplaceable. Red blood cells as immune cells can promote the killing activity of NK cells, enhance the non-specific immune effect of CD8+ T cells, and may kill a small number of viruses that have not yet reached the infection threshold.
Through "hematopoietic enhancement", "non-specific immunity" and "infection threshold" and combined with the antiviral effect of plant extracts, the ability of the pig immune system to resist diseases can be greatly improved.
"Reference Materials"
1. Liu Zhengxu, Huo Yongjiu, Yu Lihuai, et al. The biological functions of plant extracts on pigs and their related mechanisms[J].Journal of Animal Nutrition, 2014, 26(11):3209-3216.
2. Sun Jianning. Pharmacology of Traditional Chinese Medicine[M]. China Press of Traditional Chinese Medicine, 2006.
3. Guo Feng. Modern Red Cell Immunology[M]. Second Military Medical University Press, 2002.
4. Mao Yu, Xu Fang, Zou Yun, et al. Study on the influence of angelica polysaccharides on hematopoietic function and its mechanism[J]. Food Research and Development, 2015(08):122-126.
5.Liu Y, Song M, Che T M, et al. Anti-inflammatory effects of several plant extracts on porcine alveolar macrophages in vitro1[J]. Journal of Animal Science,2012,90(8):2774-2783.
6. Yao Yong, Li Xinghua. The clinical significance of serum TNF-α and red blood cell immune function detection before and after red blood cell transfusion in patients with aplastic anemia[J]. Chinese Medical Guide,2013,34(11):16-17.
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